Napoli change tactics again to a 4-4-2 with Giacomo Raspadori joining Romelu Lukaku and Scott McTominay, as Lecce welcome back Nikola Krstovic.
It kicks off at the Stadio Via del Mare at 17.00 UK time (16.00 GMT, 18.00 CET).
You can follow all the build-up and action as it happens from all today’s four Serie A games on the Liveblog.
The last two weeks were potentially decisive in the Scudetto race, as Napoli went from three points behind Inter, to joint leaders, to three points clear at the top.
Now they face a tricky trip to Lecce, who are struggling badly on and off the field, where last week they were hit by the tragic death of their long-time physio Graziano Fiorita.
They protested at being forced to play Atalanta just days after the unexpected shock, wearing white shirts with an angry message about the values being trampled by this pressure to rush their return.
Lecce desperate for points
Star striker Nikola Krstovic and midfielder Medon Berisha return from suspension, while Nicola Sansone is back in the squad months after being frozen out.
-This is because Gaby Jean and Filip Marchwinski are out for the rest of the season with serious knee injuries.
Ante Rebic is fit for the bench after suffering from flu symptoms.
Napoli are forced to again do without Alessandro Buongiorno, who only just made his comeback from a different injury.
David Neres and Juan Jesus are also sidelined, but Andre Frank Zambo Anguissa is ready to start.
Raspadori gets the nod in a switch to the 4-4-2 formation for Antonio Conte, as they are short of centre-backs and prefer Matias Olivera there to Rafa Marin.
Lecce vs. Napoli official line-ups
Lecce: Falcon; Guilbert, Gaspar, Baschirotto, Gallo; Coulibaly, Pierret, Kaba; Pierotti, Kristovic, Karlsson
Napoli: Meret; Di Lorenzo, Rrahmani, Olivera, Spinazzola; Politano, Anguissa, Lobotka, MCTOMINAY; Raspadori, Lukaku
